Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 351003-36-6, name is 2-Fluoro-5-iodobenzonitrile, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H3FIN
Add bis (triphenylphosphine) palladium (II) dichloride (77 mg, 0. 11 mmol), copper (I) iodide (42 mg, 0. 22 mmol), and 3-chloro-5-ethynylpyridine, (prepared as described in PREPARATION 27), (300 mg, 2. 2 mmol) to a solution of 2-fluoro-5-iodobenzonitrile (650 mg, 2. 6 mmol) in triethylamine (4. 6 mL, 33 mmol) and heat at 60 C for 6 h. Cool to room temperature and concentrate. Purify by silica gel chromatography, eluting with 50 : 50 dichloromethane : hexanes to 90 : 10 dichloromethane : ethyl acetate, followed by a second silica gel chromatography eluting with 95 : 5 to 75 : 25 hexanes : ethyl acetate, to give the title compound as an off-white solid (510 mg, 91%). 1H NMR (300 MHz, CH30H-d4) 8 7. 40-7. 48 (t, J = 8. 9 Hz, 1H), 7. 88-7. 97 (m, 1H), 8. 00-8. 09 (m, 2H), 8. 55-8. 58 (d, J = 2. 3 Hz, 1H), 8. 63-8. 66 (d, J = 1. 7 Hz, 1H) ; MS (APCI) : nz/z = 257 [M+H] +.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/94822; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com