Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2142-70-3, name is 1-(2-Iodophenyl)ethanone, A new synthetic method of this compound is introduced below., Recommanded Product: 1-(2-Iodophenyl)ethanone
The title compound (S6) was synthesized via modification to a general literature procedure.6 Aflame-dried Schlenk flask equipped with a magnetic stir bar was charged with anhydrouspotassium tert-butoxide (14.6 mmol, 1.64 g, 1.20 eq.) and methyltriphenylphosphonium bromide(14.6 mmol, 5.23 g, 1.20 eq.). The flask was placed under vacuum, backfilled with nitrogen, andthen placed in a 0C ice-water bath. Anhydrous THF (16 mL) was added down the side of theflask and the bright yellow mixture was stirred at 0C for 45 minutes. Then a solution of 2?-iodoacetophenone (12.2 mmol, 1.74 mL, 1.00 eq.) in anhydrous THF (8 mL) was added dropwise.The solution was gradually warmed to room temperature with stirring for 16 h. Thesolution was filtered, the filtrand washed with diethyl ether, and the resulting filtrateconcentrated in vacuo. The crude residue was purified by silica gel column chromatography(hexanes; Rf = 0.65) to provide the desired 1-iodo-2-(prop-1-en-2-yl)benzene (S6) as a clear,colorless oil in 89% yield (2.64 g).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Moyer, Brandon S.; Gagne, Michel R.; Synlett; vol. 28; 18; (2017); p. 2429 – 2434;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com