Related Products of 52807-27-9, These common heterocyclic compound, 52807-27-9, name is 4-Chloro-2-iodoanisole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of the aryl halide (0.6 mmol), arylboronic acid (2.5 equiv), Mo(CO)6 (1.5 equiv), DIPEA (3.0 equiv), palladacycle 1 (1 mol % Pd), and water (1.0 mL) was heated in a pressure tube at 140 C under microwave irradiation. The reaction was monitored by TLC. When the reaction has completed, the reaction mixturewas cooled to room temperature, poured into EtOAc (20 mL) and washed successively with water (310 mL). The organic layer was dried over anhydrous MgSO4, filtered and concentrated. The crude product was then purified by column chromatography to give pure 4.
The synthetic route of 52807-27-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ang, Wei Jie; Lo, Lee-Chiang; Lam, Yulin; Tetrahedron; vol. 70; 45; (2014); p. 8545 – 8558;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com