Some tips on Methyl 2-Iodo-5-methylbenzoate

Statistics shows that Methyl 2-Iodo-5-methylbenzoate is playing an increasingly important role. we look forward to future research findings about 103440-52-4.

Electric Literature of 103440-52-4, These common heterocyclic compound, 103440-52-4, name is Methyl 2-Iodo-5-methylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Add 1.65 g (10 mmol) to a 250 mL round bottom flask.2-Amino-5-methylbenzoic acid methyl ester, 6.07 g (22 mmol)Methyl 2-iodo-5-methylbenzoate, 3.32 g (24 mmol) potassium carbonate,0.26 g (4 mmol) of activated copper powder and 100 mL of o-dichlorobenzene,Degas the reaction system and then protect it with argon.The mixture was heated to 180 C with stirring and the reaction was continued for 72 h. After the reaction is complete,The system was cooled to room temperature, suction filtered under reduced pressure and the residue was washed with dichloromethane.After the filtrate is dried,With dichloromethane:The petroleum ether = 4:1 (volume ratio) eluent was separated and purified on a silica gel column.Obtained a yellow solid 3.38g,The yield was 73.2%.

Statistics shows that Methyl 2-Iodo-5-methylbenzoate is playing an increasingly important role. we look forward to future research findings about 103440-52-4.

Reference:
Patent; Soochow University (Suzhou); Liao Liangsheng; Yuan Yi; Jiang Zuoquan; (46 pag.)CN109456326; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com