Related Products of 1878-69-9,Some common heterocyclic compound, 1878-69-9, name is 2-(3-Iodophenyl)acetic acid, molecular formula is C8H7IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
lll.delta.a 2-(3-iodophenyl)ethanol A solution of 9.3 g (33.7 mmol) (3-iodophenyl)acetic acid is dissolved in 160 ml dry THF and cooled to 00C. Then 34,0 ml of a 1 ,0 M solution of lithium aluminumhydride in THF (34,0 mmol) is slowly added. The reaction mixture is allowed to warm to room temperature and stirred for 2 hours. The excess lithium aluminumhydride is carefully destroyed with a few drops of water and the resulting mixture is filtered through celite. The solvent is removed in vacuo leaving the crude product, which is used without further purification in the next step. Yield: 6.83 g (81% of theory), C8H9IO EII mass spectrum: m/z = 249 [M+H]+
The synthetic route of 1878-69-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/71646; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com