Adding a certain compound to certain chemical reactions, such as: 58755-70-7, name is 1-Iodo-4-methoxy-2-nitrobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 58755-70-7, Formula: C7H6INO3
Compound A 1.8 mmol and compound B 1.5 mmol were added to 5 mL of dry N,N-dimethylformamide. Then, 2 mL of triethylamine and 105 mg of bis(triphenylphosphine)palladium(II) chloride were successively added thereto. Degassing operation under nitrogen protection, rapidly adding 0.2 mmol of cuprous iodide and 0.01 g of manganese tetroxide. The reaction was carried out under nitrogen atmosphere for 3 h. Filtration, to the filtrate was added 60 mL of ethyl acetate then washed. The organic layer was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The organic layer was dried with a rotary evaporator. The crude C was placed in the separation of the column, eluent was dichloromethane-methanol 100: 1, 50: 1 (v: v) gradient, to obtain a white solid C.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-4-methoxy-2-nitrobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ITIC Medchem (Suzhou) Co., Ltd.; Hu, Haiwei; Ding, Jing; Yan, Yongping; Zheng, Hui; Yan, Hui; (11 pag.)CN105669525; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com