Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27913-58-2, name is 4-(4-Iodophenyl)butanoic acid, A new synthetic method of this compound is introduced below., Product Details of 27913-58-2
To an ice-cooled THF (20 mL) mixture of 4- (4-iodophenyl) butanoic acid (1) (2.90 g, 10.0 mmol) was added borane-tetrahydrofuran complex (20 mL, 1.0 M, 20 mmol) dropwise over 30 min. The resulting mixture was stirred for 1.5 hr at room temperature, and then quenched with a 1: 1 HOAc/MeOH (1 mL). The solvent was stripped, and the residue was then partitioned between EtOAc and water. The organic layer was separated, washed with saturated [NAHCO3] and brine, dried over [MGS04,] and evaporated to produce a quantitative yield of the crude alcohol as an oil. To a [CH2CL2] (12 mL) mixture of the crude alcohol (1.75 g, 6.3 mmol) was added [4-METHYLMORPHOLINE] N-oxide (1.11 g, 9.5), 4 [A] powdered molecular sieves (3 g), and tetrapropylammonium [PERRUTHENATE] (“TRAP”, [0.] [11 G,] 0.3 mmol). The resulting slurry was stirred for 1 hr at room temperature. The crude material was purified on silica gel (eluting with 5-50% ethyl acetate in hexane) to afford 1.11 g (64% yield) of the desired aldehyde product (2) as an oil. LCMS : m/z = 257.0 (M+H- H20).
The synthetic route of 27913-58-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMACIA CORPORATION; WO2004/811; (2003); A1;,
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