Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 101066-87-9, name is 4-Iodo-2-(trifluoromethyl)benzonitrile, A new synthetic method of this compound is introduced below., Safety of 4-Iodo-2-(trifluoromethyl)benzonitrile
General procedure: A suspension of thiohydantoin 1 (1 mmol), aryliodide (3 mmol),copper(I) iodide (1 mmol), 1,10-phenanthroline (1 mmol), and sodiumtert-butoxide (2 mmol) in 5 ml of freshly dried dimethylformamide(DMF) was stirred for 12 h at rt with TLC checking, and then heated in the microwave oven for 30 min at 100 C. After the same work-up as above but with 100 ml of water, the product was likewise purified and recrystallized.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Aladinskiy, Vladimir A.; Averochkin, Gleb M.; Beloglazkina, Elena K.; Dlin, Egor A.; Finko, Alexander V.; Ivanenkov, Yan A.; Kalinina, Marina A.; Laikov, Dimitri N.; Majouga, Alexander G.; Mironov, Andrei V.; Skvortsov, Dmitry A.; Vorobyeva, Nataliya S.; Zyk, Nikolay V.; Bioorganic Chemistry; vol. 100; (2020);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com