In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 391211-97-5, name is 3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid
EXAMPLE 5 R3, 4-DIFLUORO-2-(2-FLUORO-4-IODO-PHENVLAM INO)-PHENYLL-(4-METHYL-OXAZOL-2-YL) methanone Step A: Synthesis of 314-DIFLUORO-2-(2-FLUORO-4-IODO-PHENVLAMINO)-BENZOYL CHLORIDE A solution of 3, 4-DIFLUORO-2-(2-FLUORO-4-IODO-PHENYLAMINO)-BENZOIC acid (5.0 g, 12.7 MMOL) in thionyl chloride (75 mL) containing 10 drops of dimethylformamide was heated at reflux for 15 min. The solvent was removed in vacuo affording 3, 4-DIFLUORO-2- (2-FLUORO-4-IODO- phenylamino)-benzoyl chloride (5.3 g, which can be prepared according to the procedure of WO 02/06213) as a yellow solid
The synthetic route of 391211-97-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; WARNER-LAMBERT COMPANY LLC; WO2005/7616; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com