Electric Literature of 52807-27-9,Some common heterocyclic compound, 52807-27-9, name is 4-Chloro-2-iodoanisole, molecular formula is C7H6ClIO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Add to a solution of 4-chloro-2-iodoanisole (10 g, 37.24 mmol) in 1,4-dioxane (50 mL) is 2-thiopheneboronic acid (5.71 g, 44.66 mmol), (2-dicyclohexylphosphino)-2′- methylbiphenyl (2.71 g, 7.44 mmol), palladium acetate (0.418 g, 1.86 mmol) and potassium fluoride (6.49 g, 111.7 mmol). Stir at 95 C for 18 h, cool to room temperature, filter through a filtering agent and wash with ethyl acetate (400 mL). Wash organic layer with water (3 x 100 mL), saturated aqueous sodium chloride (1 x 100 mL), dry over sodium sulfate, filter, concentrate and purify (HPLC, eluting with hexanes) to give the titled compound as an oil (5.4g). HRMS m/z Calculated: 225.0141; Found: 225.0132
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Chloro-2-iodoanisole, its application will become more common.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/100301; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com