Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 148836-41-3, name is 1-Bromo-4-chloro-2-iodobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Bromo-4-chloro-2-iodobenzene
The starting material 1-bromo-4-chloro-2-iodobenzene (1.58 g, 5.0 mmol), 4-chloro-1-ethynyl-2-methoxybenzene (916 g, 5.5 mmol), PdCl2(PPh3)2(70 mg, 0.1 mmol), CuI (19 mg, 0.05 mmol) and Et3N (20 mL) were stirred at room temperature for 24 hours under nitrogen. When the reaction is complete, extract the organic layer three times with diethyl ether. The extracted organic layer was dried over magnesium sulfate, and the solvent was evaporated. The resulting residue was purified by silica gel column chromatography to obtain Intermediate A-1 (1.60 g, 4.5 mmol, 90% yield). The resulting compound was identified via MS / FAB. C15H9BrCl2O cal. 356.04, found 353.92.
The synthetic route of 148836-41-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Samsung Display Co., Ltd.; Kim Hae-jin; Go Su-byeong; Jeon Mi-eun; Kim Yeong-guk; Hwang Seok-hwan; (70 pag.)KR2018/21340; (2018); A;,
Iodide – Wikipedia,
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