Reference of 13194-69-9,Some common heterocyclic compound, 13194-69-9, name is 2-Iodo-5-methylaniline, molecular formula is C7H8IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-2 (0.0103 mol) was added drop wise to a mixture of 1-1 (0.0051 mol), Pd (PPh3) 2C12 (0.0005 mol) and GuI (0.0005 mol) in Et3N (15 ml) under N2 flow. The mixture was stirred at room temperature for 4 hours, poured into H20 and extracted with EtOAc. The organic layer was washed with H20, dried (over MgSO4), filtered and the solvent was evaporated_ The residue (2.1 g) was purified by column chromatography over silica gel (eluent: CHxClz/cyclohexane 70/30). The pure fractions were collected and the solvent was evaporated Yield: 1 g of intermediate 1-3 (79%).
The synthetic route of 13194-69-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2005/58871; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com