These common heterocyclic compound, 31827-94-8, name is 2-Bromo-1-(4-iodophenyl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H6BrIO
General procedure: All 1-substituted 2-hydroxy-2-aryl-2,3-dihydro-imidazo[1,2-a]pyrimidinium salts were synthesized by using previously described protocols.41 A general procedure is described below (with compound 79 as an example): In a 30 mL microwave vial were successively brought acetonitrile (15 mL), N-(1,3-benzodioxol-5-ylmethyl)pyrimidin-2-amine (1.15 g, 5 mmol), 4-fluorophenacylbromide (1.3 g, 6 mmol, 1.2 equiv), and a catalytic amount of4-dimethylaminopyridine (6 mg, 0.05 mmol). The reaction tube was sealed and irradiated in a microwave reactor at a ceiling temperature of 80 C at 150 W maximum power for 30 min. After the reaction mixture was cooled with an air flow for 15 min, the precipitate was washed with acetone (25 mL), ether (20 mL) and dried in vacuum to afford 79 (1.98 g, 89% yield) as a white powder.
The synthetic route of 2-Bromo-1-(4-iodophenyl)ethanone has been constantly updated, and we look forward to future research findings.
Reference:
Article; Steenackers, Hans P.L.; Ermolat’Ev, Denis S.; Savaliya, Bharat; Weerdt, Ami De; Coster, David De; Shah, Anamik; Van Der Eycken, Erik V.; De Vos, Dirk E.; Vanderleyden, Jozef; De Keersmaecker, Sigrid C.J.; Bioorganic and Medicinal Chemistry; vol. 19; 11; (2011); p. 3462 – 3473;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com