Application of 14452-30-3,Some common heterocyclic compound, 14452-30-3, name is 1-(3-Iodophenyl)ethanone, molecular formula is C8H7IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Acetophenones bearing hydroxy group and or halogens were reacted with substituted benzaldehydes in the presence of 50% (w/v) KOH/H2O using ethanol as a solvent. Purification was done using column chromatography and some chalcones such as those bearing a 4-methoxy group on B-ring can even be recrystallized directly from ethyl acetate-methanol mixture, with acceptable yields ranging from 60-80%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(3-Iodophenyl)ethanone, its application will become more common.
Reference:
Article; Hsieh, Chi-Ting; Hsieh, Tusty-Jiuan; El-Shazly, Mohamed; Chuang, Da-Wei; Tsai, Yi-Hong; Yen, Chiao-Ting; Wu, Shou-Fang; Wu, Yang-Chang; Chang, Fang-Rong; Bioorganic and Medicinal Chemistry Letters; vol. 22; 12; (2012); p. 3912 – 3915;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com