Application of 98-61-3,Some common heterocyclic compound, 98-61-3, name is 4-Iodobenzenesulfonyl chloride, molecular formula is C6H4ClIO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of 7 (1.0 eq) and triethylamine (3.5 eq) in dichloromethane (10 volume), substituted sulphonyl chloride (1.2 eq) was added at 5-10 C and stirred overnight at room temperature.The completion of the reaction was confirmed by TLC. The reaction mixture was poured into separating funnel washed with water followed by brine solution, dried over anhydrous sodium sulphate and concentrated to syrup. Crude syrup was purified by crystallization using dichloromethane and petroleum ether to yield the oxadiazole substituted sulfonamide as white to white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodobenzenesulfonyl chloride, its application will become more common.
Reference:
Article; Harish, Kikkeri P.; Mohana, Kikkeri N.; Mallesha, Lingappa; Prasanna Kumar, Basavapatna N.; European Journal of Medicinal Chemistry; vol. 65; (2013); p. 276 – 283;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com