Adding a certain compound to certain chemical reactions, such as: 103962-05-6, name is 1-Iodo-4-(trifluoromethoxy)benzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 103962-05-6, name: 1-Iodo-4-(trifluoromethoxy)benzene
General procedure: A Schlenk tube was charged with a mixture of tetrahydroberberrubine (1, 228 mg,0.70 mmol), potassium carbonate (97 mg, 0.70 mmol), copper(I) iodide (13 mg,0.07 mmol), picolinic acid (17 mg, 0.14 mmol), aryl iodide (1.40 mmol, 2 equiv) andDMSO (6 mL) before it was evacuated and backfilled with N2 for three times. Thereaction mixture was stirred for 24 h at 100 C and the resulting mixture was subjectedto column chromatography (SiO2, CH2Cl2/MeOH 200:1-150:1) to give the respectiveproduct 2a-o as pale-yellow solids and 4 as yellow solid. Characterization data and theoriginal spectra are presented below.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Article; Teng, Qiaoqiao; Zhu, Xinhui; Guo, Qianqian; Jiang, Weihua; Liu, Jiang; Meng, Qi; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 1575 – 1580;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com