Synthetic Route of 199850-56-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 199850-56-1, name is Methyl 2-amino-4-chloro-5-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
LODINATION of aniline containing compounds: LODINATION was accomplished using a procedure similar to that set forth in the following reference which is herein incorporated by reference in its entirety for all purposes as if fully set forth herein: J. Med. Chem. 2001,44, 6,917-922. The ANTHRANILIC ester in EtOH was added to a mixture of silver sulfate (1 equivalent) and 12 (1 equivalent). The reaction was typically done after 3 hours at room temperature. The reaction was filtered through Celite and concentrated. The residue was taken up in EtOAc and washed with aqueous saturated NAHC03 (3x), water (3x), brine (1X), dried (MGS04), filtered, and concentrated. The crude product (-5 g) was dissolved in MeOH (60-100 mL), NAOH 6 N (25 mL), and water (250 mL). The reactions were typically done after heating at 70-80 C for 4 hours. The reaction mixture was extracted with EtOAc (2x), neutralized with aqueous HCI, filtered to collect the solids, and the solid products were washed with water. The products were dried in vacuo.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-amino-4-chloro-5-iodobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CHIRON CORPORATION; WO2004/18419; (2004); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com