Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 450412-28-9, name is 1-Bromo-3-chloro-2-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows., Formula: C6H3BrClI
A sdution of 5-(44,5,5-tetramethy-1 32-doxabordan-2-yndohn-2-one (250 mg, 0.96 mmd), 1-bromo-3-choro-2-odobenzene (373mg, 1.2 mmd), and potassum phosphate (410 mg, 1.9 mmd) n 4:1 doxane: water (3.0 rnL) was degassed with n[trogen for 10 minutes. PdC2(dppf)-CH2C2 (35 mg, 0.05 mmd) was added at once and the resuWng mixture was degassed w[th n[trogen for an add Wona 10 minutes. The reacUon rnxturewas heated at 100 C for 16 h. After coohng to rt, water was added and the aqueous ayer was extracted w[th DCM (x3). The combined orgadc extracts were dried over Na2SO4 and concentrated n vacuo. Purflcafion (FCC, SO2; 0 50% EtOAc/hexanes) provided the tWe compound as a white sohd (189 mg, 61% yed). MS (ES): mass cacd. for C14H9BrCNO, 321.0; rn/z found. 321.9 [M+Hj. 1H NMR (500 MHz, DMSO-d6) oe 10.50 (5,IH), 772(dd, J=8.1, 1.1 Hz, IH), 760 (dd, J=8.1, 1.1 Hz, IH), 7.32(t, J=8.1 Hz, IH),7.11 -6.97 (m, 2H), 6.91 (dd, J=8.0, 0.6 Hz, IH), 353 (5, 2H).
According to the analysis of related databases, 450412-28-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; AMERIKS, Michael K.; RAVULA, Suchitra; SAVALL, Bradley M.; SWANSON, Devin M.; ZIFF, Jeannie M.; SHIREMAN, Brock T.; (167 pag.)WO2016/176463; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com