Synthetic Route of 6828-35-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6828-35-9 as follows.
1 mmol of 5-chloro-2-iodoaniline, 3 mL of aqueous ammonia at a concentration of 12 mol / L was added to the reaction vessel, 4-methylbenzaldehyde mmol, 0.1 mmol of copper chloride, 0.1 mmol of proline lithium, 1 mmol of sodium hydroxide, 3 mL of water and 1 mL of water. Placed in a microwave reactor at 150 w of power heated to 100 C for 15 min continuous reaction. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The product was purified by column chromatography to give a white solid in 84% yield.
According to the analysis of related databases, 6828-35-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Fujian Medical University; Ke Fang; Zhang Peng; Xu Jianhua; Wu Wen; Zheng Yu; Wu Lixian; (9 pag.)CN106866543; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com