Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20555-91-3, name is 1,2-Dichloro-4-iodobenzene, A new synthetic method of this compound is introduced below., category: iodides-buliding-blocks
General procedure: To a screw-capped vial (50 ml) were added aryl iodides 1(1.0 mmol), benzonitrile 2a (155 mg, 1.5 mmol), K2CO3 (276 mg,2.0 mmol), NaOH (40 mg,1.0 mmol), CuI (19 mg, 0.1 mmol), DMEDA(9 mg, 0.1 mmol), and [bmim]PF6 (14 mg, 0.05 mmol) in water(2 ml). The vial was flushed with nitrogen then sealed with the cap,and allowed to stir at 100 C for the specific reaction time. Thereaction mixture was extracted with EtOAc (315 ml). The combined organic extracts were dried over Na2SO4 for 12 h andevaporated under vacuum. The crude products were purified ina silica gel column for further purification, using PE/EtOAc (5:1) asthe eluent.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Wang, Jichao; Yin, Xinchi; Wu, Jun; Wu, Datong; Pan, Yuanjiang; Tetrahedron; vol. 69; 48; (2013); p. 10463 – 10469;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com