Electric Literature of 162358-07-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 162358-07-8, name is 1-(2-Iodoethyl)-4-octylbenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
(1) Ethyl 2-Ethoxycarbonyl-4-(4-octylphenyl)butyrate Sodium (2.67 g) was dissolved in absolute ethanol (100 ml) and diethyl malonate (18.6 g) was dropwise added thereto at 27-30 C. for 3 minutes. The mixture was stirred at 40 C. for 40 minutes and 2-(4-octylphenyl)ethyl iodide (40 g) was dropwise added to the reaction mixture at 44-45 C. over 10 minutes. The mixture was refluxed at 50 C. for 1 hour and stirred under heating for 1.5 hours. The reaction mixture was cooled and the solvent was distilled away under reduced pressure. Water was added thereto and extracted with ethyl acetate. The extract was washed with water and dried over magnesium sulfate. The solvent was distilled away under reduced pressure and the residue obtained was subjected to silica gel column chromatography to give the subject compound (28.8 g). IR: 2920, 2850, 1745, 1725, 1240, 1140, 1040 cm-1.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(2-Iodoethyl)-4-octylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Yoshitomi Pharmaceutical Industries, Ltd.; Taito Co., Ltd.; US5604229; (1997); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com