Introduction of a new synthetic route about

Application of 167479-01-8,Some common heterocyclic compound, 167479-01-8, name is tert-Butyl (3-iodopropyl)carbamate, molecular formula is C8H16INO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under a nitrogen atmosphere, cesium carbonate (10.13 g, 31.07 mmol) was added to a suspension of 2-propyl[l,3]thiazolo[4,5-c]quinolin-7-ol (5.06 g, 20.7 mmol) in DMF (110 mL), and the reaction mixture was heated at 65 0C. A solution of tert-butyl 3- iodopropylcarbamate (7.08 g, 24.8 mmol) in DMF (20 mL) was added dropwise with stirring. The reaction mixture was stirred at 65 C overnight. The solvent was then removed under reduced pressure at 65 0C. The resulting solid was partitioned between dichloromethane (250 mL) and water (250 mL). The organic layer was washed EPO sequentially with saturated aqueous sodium thiosulfate (100 mL), water (100 mL), and brine (100 mL); dried over magnesium sulfate; filtered; and concentrated under reduced pressure. The resulting solid was purified by column chromatography on silica gel (eluting with 0 to 4% methanol in chloroform) to provide 5.36 g of tert-butyl 3-[(2- propyl[l,3]thiazolo[4,5-c]quinolin-7-yl)oxy]propylcarbamate as a light yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl (3-iodopropyl)carbamate, its application will become more common.

Reference:
Patent; 3M INNOVATIVE PROPERTIES COMPANY; WO2006/86449; (2006); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com