Some common heterocyclic compound, 2142-70-3, name is 1-(2-Iodophenyl)ethanone, molecular formula is C8H7IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-(2-Iodophenyl)ethanone
The operation method of the specific synthesis is the same as that in Example 1, specifically: 1-(2-iodobenzene) ethyl-1-one (1 mmol) and 50 mL of trifluorotoluene are added to the flask,Stir to dissolve 1-(2-iodobenzene) ethyl-1-one in trifluorotoluene, then add 2N HCl (0.5mL),Then, sodium dichromate (0.30g) was added under acidic conditions, heated to 95C and reacted under reflux at this temperature for 6h.After the reaction, spin off the trifluorotoluene in the system, add sodium hydroxide to the water phase to adjust the water phase to pH 9 to remove impurities, and then add hydrochloric acid to the water phase to adjust the water phase to pH 3,After extraction and recrystallization from petroleum ether, the product 2-(2-iodobenzene)-2-glyoxylic acid was obtained with a yield of 86%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2142-70-3, its application will become more common.
Reference:
Patent; Suzhou Aimate Biological Technology Co., Ltd.; Wang Mingzhong; Zhu Mingxin; Su Dao; Li Jinjin; (13 pag.)CN111116358; (2020); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com