Month: May 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 391211-97-5, name is 3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid

EXAMPLE 6 1-F3, 4-DIFLUORO-2- (2-FLUORO-4-VINVIPHENYLAMINO)-PHENVLL-2-HYDROXV-ETHANONE Step A: Synthesis of R3, 4-DIFLUORO-2- (2-FLUORO-4-IODOD-PHENYLAMINO)-PHENVLL- methanol. To 3, 4-DIFLUORO-2-(2-FLUORO-4-IODO-PHENYLAMINO)-BENZOIC acid (10. 0g, 25. 4MMOL) in tetrahydrofuran was added, borane in tetrahydrofuran (38.2mL of a 1. OM solution) after 16 hours stirring at room temperature, the reaction was complete and quenched by careful addition of 2% HCI (100ML). The mixture was stirred for 1 H, brine was added and the organic layer was separated which was dried and evaporated to give a colorless solid (7. 13g 74%) that was recrystalized from hot dichloromethane/hexane to give an analytical sample. MS (APCI+) 380 (M+1+) ; H NMR (400mHz, DMSO) 7.62 (s, 1H), 7.50 (d, 1H), 7.24 (m, 3H), 6.29 (d of t, 1 H), 5.35 (t, 1 H), 4.42 (d, 1 H).

According to the analysis of related databases, 391211-97-5, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 2468-56-6, name is 6-Iodohex-1-yne, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2468-56-6, Product Details of 2468-56-6

A mixture of 4,4?-bipyridine (1.0 g, 6.4 mmol) and 6-iodo-1-hexyne (4.6 g, 22 mmol)in dry MeCN (30 mL) was heated at 105 oC / 6 psi under N2 for 3 h. The reaction mixture was cooled to room temperature and the resulting reddish precipitate was filtered and washed thoroughly with MeCN. The solid was dissolved in H2O (100 mL), followed by the addition of excess of NH4PF6, resulting in the precipitation of an off-white solid which was collected by centrifugation, washed with H2O (3 × 20 mL), MeOH (1 × 20 mL) and dried in vacuo to yield HV?2PF6 as a light brown solid (2.4 g) in 62% yield

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Iodohex-1-yne, and friends who are interested can also refer to it.

Related Products of 13194-69-9, The chemical industry reduces the impact on the environment during synthesis 13194-69-9, name is 2-Iodo-5-methylaniline, I believe this compound will play a more active role in future production and life.

General procedure: 2-Iodoaniline 2a (65.7 mg, 0.3 mmol), Cu(OAc)2 (6 mg, 10%), KOtBu (101 mg, 0.9 mmol), DMAc (1.0 mL) were mixed in a Schlenck tube and then to the mixture was added 2-(phenylethynyl)benzonitrile1a (74 mg, 0.36 mmol) under N2. The reaction mixture was stirred for 12 h at 120 C under N2. After the reaction was completed (monitored by TLC), the reaction mixture was then diluted with water and extracted with ethyl acetate. After the combined organic layers were washed with brine, dried over Na2SO4, and concentrated under reduced pressure, the residue was purified by flash column chromatography on silica gel using petroleum ether/ethyl acetate as eluent to afford the pure product 3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodo-5-methylaniline, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19230-50-3, name is 2-Iodo-5-nitrobenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Iodo-5-nitrobenzoic acid

H. 2-Iodo-5-Nitroso-Benzamide The synthesis of 2-iodo-5-nitroso-benzamide can be performed similarly to the synthesis of 4-iodo-3-nitroso-benzamide, described above, using 2-iodo-5-nitro benzoic acid (Chemica Alta Ltd., Edmonton, Alberta, Canada) as the starting material.

The synthetic route of 19230-50-3 has been constantly updated, and we look forward to future research findings.

Related Products of 627-32-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 627-32-7, name is 3-Iodo-1-propanol belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 1 -(4-hydroxyphenyl)-3 -methyl-i H-pyrazole-4-carbaldehyde (214 mg, 1.057 mmol, 1 eq.), 3-iodopropan-i-ol (1.27 g, 1.268 mmol, 1.2 eq), K2C03 (292 mg, 2.114 mmol, 2 eq.) in 5 mL CH3CN was heated at reflux for 24 h. The mixture was thenfiltered, and the remaining solid was washed with EtOAc twice (10 mL each time). The organic layers were concentrated and purified using silica column chromatography to afford 1 -(4-(3 -hydroxypropoxy)phenyl)-3 -methyl-i H-pyrazole-4-carbaldehyde as a yellow solid (190 mg, yield: 69%). ?H NIVIR (CDC13) oe (ppm) 2.04-2.12 (m, 2H), 2.55 (s, 3H), 3.86-3.90 (t, 2H), 4.15-4.19 (t, 2H), 7.03 (d, J= 9.0 Hz, 2H), 7.34 (d, J= 9.0 Hz,2H), 8.03 (s, 1H), 9.96 (s, 1H); ?3C NIVIR (CDC13) oe (ppm) 11.55, 31.88, 59.94, 65.77,114.97, 121.48, 126.74, 131.18, 142.13, 143.41, 159.13, 184.94;ESI-MS(M+H)m/z=261.0.

The synthetic route of 3-Iodo-1-propanol has been constantly updated, and we look forward to future research findings.

Related Products of 90347-66-3, These common heterocyclic compound, 90347-66-3, name is Methyl 3-iodo-4-methylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-iodo-4-methylbenzoic acid. Methyl-3-Iodo-4-methylbenzoate (3 g, 109 mmol, 1 eq) dissolved in MeOH (30 ml) was added sodium hydroxide (1.3 g, 327 mmol, 3 eq) followed by the addition of water (15 ml). The above solution was stirred at room temperature for 14 h. The solution was concentrated under vacuum, and then added water. The pH of the reaction was bought to 3 using Cone. HCl. The solid obtained was filtered and dried under vacuum, Yield: 2.7 g (96 %). 1HNMR (400MHz, DMSO-d6): delta 2.44 (s, 3H), 7.45 (d, 7- 8.00 Hz ,1H), 7.85 (d, J= 3.18 Hz, IH), 8.31 (s, IH).

Statistics shows that Methyl 3-iodo-4-methylbenzoate is playing an increasingly important role. we look forward to future research findings about 90347-66-3.

Synthetic Route of 175278-11-2, A common heterocyclic compound, 175278-11-2, name is 1-Bromo-3,5-difluoro-2-iodobenzene, molecular formula is C6H2BrF2I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a cooled solution of l-bromo-3,5-difluoro-2-iodobenzene (10.0 g, 31.4 mmol) in THF (25 mL, 1.3 M) at -20 C was added a solution of iPrMgCl (2M in THF, 20.4 mL, 40.8 mmol) dropwise. The mixture was stirred for 10 min and then warmed to 0 C and stirred an additional 50 min. Copper iodide (1.49 g, 7.84 mmol) was added, and the mixture was stirred for 10 min. Ethyl 2-(bromomethyl)acrylate (6.36 g, 4.55 mL, 32.9 mmol) was added, and the mixture was warmed to room temperature and stirred overnight. The reaction was quenched with sat. aq. NH4C1 (25 mL), diluted with EtOAc (25 mL) and extracted with EtOAc (3 x 30 mL). The combined organics were washed with brine (4 x 50 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The resulting residue was purified by silica gel column to give the desired product l-bromo- 3,5-difluoro-2-(2-methylallyl)benzene as a colorless and clear oil (10 g). Yield >95%.

The synthetic route of 175278-11-2 has been constantly updated, and we look forward to future research findings.

Reference of 39959-51-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39959-51-8 name is (2-Iodophenyl)methanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 2-/3-/4-Iodobenzyl chloride (1a-c) was dissolved in chloroform containing 1.1 equivalents of triethylamine. A solution of substituted benzoyl chloride (2a-g) in chloroform was added dropwise with stirring over 15min. The precipitate that formed was removed by filtration and the resulting filtrate was washed sequentially with water, 1N hydrochloric acid, 5% sodium carbonate and brine. The organic phase was dried over magnesium sulfate (anhyd.), filtered, evaporated to dryness and the resultant 2-/3/-4-substituted-N-(2/3/4-iodo)- benzylbenzamide 3a-i was recrystallized from alcohol. To obtain the corresponding 2-/4-iodo-N-substituted benzyl benzamide derivatives, the same procedure was followed, except that the 2-/4-iodobenzoyl chlorides 2h,2i and isomeric 2-/4-methoxybenzylamines 1d,1e were used. All new compounds 3a-i and 4a-d were characterized by 1H, 13C NMR spectrometry, and elemental analysis or LC-MS.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (2-Iodophenyl)methanamine, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6326-42-7, name is Methyl 2-iodo-4-nitrobenzoate, A new synthetic method of this compound is introduced below., SDS of cas: 6326-42-7

A solution of the compound 8 (10.0 g, 32.57 mmol) and SnCl2. 2 hi) (22.04 g, 97,69 mmol, 3 equiv.) in EtOAc ( 150 mL) was refluxed for 5 hours until TLC (EtOAc/hexane, 1 : 1) indicated that reaction was complete. The reaction mixture was poured in a 500 ml beaker and it was diluted with 100 ml of EtOAc followed by the addition of potassium carbonate and 200 ml of deionized water and the two layer mixture was stirred for 30 minutes. The milky suspension was filtered through a short bed of CELITE and the organic layer was separated. The combined organic layer was sequentially treated with saturated brine and anhydrous Na2S0 . Purification by flash column chromatography using EtOAc: petroleum ether (1 : 1) afforded a pale yellow solid 9 (5.86 g, 65% yield). [0396] FontWeight=”Bold” FontSize=”10″ 1I NMR (400 MHz, CDC13, TMS) delta 3.86 (s, 3H), 4.01 (broad singlet, 2H), 6.58-6.64 (dd, IH, Jj = 2.29 Hz, J2 = 8.70 Hz), 7.30 (d, 1H, J = 2.29 Hz), 7.77 (d, 1H, J – 8.24 Hz). 1 C NMR (100 MHz, CDC13) delta: 51.87, 96.53, 1 13,44, 127,03, 132.95, 150,24, 165,92, MS (ESI): m/z (%) 300. 9 (M Xa }

The synthetic route of 6326-42-7 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32024-15-0, name is 3-Iodo-4,5-dimethoxybenzaldehyde, A new synthetic method of this compound is introduced below., COA of Formula: C9H9IO3

(3-Iodo-4,5-dimethoxyphenyl)methanoI (3). A method of Chowdhury and co-workers was modified. A 250 mL, three-necked, round-bottomed flask, equipped with a magnetic stir bar and a condenser was charged with 2 (25 g, 85 mmol) and 100 mL of THF. Sodium borohydride (1.91 g, 50 mmol) was added slowly portion- wise over a period of 5 min and the reaction mixture was stirred at room temperature for 45 min. The reaction mixture was quenched with 100 mL of saturated NH4C1 and extracted with ethyl acetate (3 x 125 mL). The combined organic layers were washed with saturated NaCl (100 mL), dried (MgS04) and concentrated under vacuum to yield 3 (24.8 g, 98.8%) as a thick colorless liquid. IR: 3392, 2824 cm”1; H-NMR(CDC13): delta 7.27 (d, J= 1.6 Hz, 1H), 6.86 (d, J = 1.6 Hz, 1H), 4.53 (s, 2H), 3.83 (s, 3H), 3.79 (s, 3H), 2.83 (br s, 1H); I3C-NMR (CDC13): 5 152.4, 147.7, 139.0, 128.3, 111.2, 92.1, 63.9, 60.3, 55.8.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.