Month: May 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H6IN

General procedure: A stirred mixture of 4-iodophenylacetonitrile (35), arylboronic acid (36-45) (1.1 equiv), Pd(PPh3)4 (0.03 equiv), KBr (1.1 equiv), and K3PO4 (2.5 equiv) in dioxane (5 mL/mmol) was purged with N2 for10 min at room temperature and then stirred overnight at 85 C under N2. The mixture was diluted with water and extracted with AcOEt. The organic phase was washed three times with water, dried (Na2SO4), and evaporated under vacuum. The residue was chromatographedon silica gel.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 51628-12-7.

Reference of 461-17-6,Some common heterocyclic compound, 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane, molecular formula is C4H6F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

l-(2,4-Dichlorophenyl)-5-(4-hydroxyphenyl)-4-methyl-lH-pyrazole-3-carboxylic acid piperidin-l-yl amide from 1, Step F (250 mg, 0.56 mmol) was dissolved in acetone (10 ml) and potassium carbonate (77 mg, 0.56 mmol) was added followed by l-iodo-4,4,4- trifluorobutane (140 mg, 0.56 mmol). The reaction mixture was boiled under reflux overnight, concentrated and purified by flash chromatography (hexane : EtOAc 70 : 30 – 60 : 40) afforded 130 mg (42%) of a white solid that was triturated with hexane : EtOAc 95 : 5 and filtered.1H NMR(CDCl3): 5 7.63 (IH, broad s), 7.43 (IH, m), 7.30 (2H, m), 7.10-7.00 (2H, m), 6.85-6.78 (2H, m), 4.05 (2H, t), 2.90 (4H, m), 2.40-2.19 (5H, s and m), 2.15-1.97 (2H, m), 1.78 (4H, m), 1.45 (2 H, m). MS m/z 577 (M+Na). HPLC: 98.4%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,1-Trifluoro-4-iodobutane, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 626-62-0, name is Iodocyclohexane, A new synthetic method of this compound is introduced below., Product Details of 626-62-0

General procedure: A mixture of alkyl/aryl halide, 1 (1.2 mmol), ammonium hydroxide (1 mmol) and nanosulfur powder (3 mmol, 96 mg) was stirred in 5mL of solvent (ethanol/water (2:1)) at 60 C. Under this stirring condition indium oxide nanoparticles (3 mol-%) were added to it and the reaction was stirred for a period of 10 min to 1 h at 60 C. After completion of the reaction as indicated by thin layer chromatography (TLC), the reaction mixture was cooled to room temperature and a 2:1 mixture of ethyl acetate/water (15 mL) was added and indium oxide was removed by centrifuge. The combined organic extracts were dried with anhydrous sodium sulfate and concentrated to give desired product in high purity.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

1878-69-9, name is 2-(3-Iodophenyl)acetic acid, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C8H7IO2

To a solution of 3-iodorhohenylacetic acid (24.8 g, 94.6 mmol) in CH2Cl2 (200 mL) was added oxalyl chloride (189 mmol, 2 equiv), followed by a drop of DMF. The mixture was stirred at room temperature for Ih and then concentrated. Addition of ethanol and purification by flash chromatography (EtOAc/Hex) gave yellow oil as product. 1H NMR (600 MHz, CDCl3): delta = 7.63 (s, 1 H), 7.59 (d, 1 H), 7.25 (d, 1 H), 7.04 (t, 1 H), 4.16 (q, 2 H), 3.53 (s, 2 H), 1.25 (t, 3 H); LRMS: m+1 (291.0, 4.228 min.).

The synthetic route of 1878-69-9 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C8H6IN

1L pressure kettle,121.5 g (0.5 mol) of p-iodophenylacetonitrile,800 g (2 mol) of 10% sodium hydroxide,10.9 g (0.075 mol) of 8-hydroxyquinoline,12.8g (0.075mol) after adding copper chloride, the kettle heated to 50 ~ 55 , to maintain The pressure of the reactor is 0MPaG, the temperature of the reaction system is kept between 50 and 55 DEG C, and the reaction is carried out for 7 hours. The reaction solution is finished and the reaction vessel is cooled. The pH of the reaction solution is adjusted to between 7 and 8 with 36% hydrochloric acid. The mother liquor was adjusted to pH with 30% NaOH13 ~ 14, get dark red transparent liquid, sodium p-hydroxyphenylacetate solution, weighing 755g, the detection of p-hydroxyphenylacetic acid content of 9.79%, the yield was 97.3%.

According to the analysis of related databases, 51628-12-7, the application of this compound in the production field has become more and more popular.

Application of 260355-20-2,Some common heterocyclic compound, 260355-20-2, name is 1-Chloro-4-iodo-2-(trifluoromethyl)benzene, molecular formula is C7H3ClF3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The 1-chloro-4-iodo-2-trifluoromethylbenzene (10 mmol) obtained in the reaction 1.2 was dissolved in 20 ml of toluene, and the system was sequentially added with isoxazol-4-amine (12 mmol), palladium acetate ( 0.5 mmol), 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (12 mmol), 3 ml of triethylamine. After stirring for 10 minutes, add 10 ml of cesium carbonate (10 mmol). The aqueous solution is heated to 50 C for 4 hours. After the reaction is completed, 20 ml of water is added to the system, stirred for 20 minutes, and the organic phase is dried over anhydrous sodium sulfate, concentrated, and then purified by flash column chromatography.2.2 g of yellow N-(4-chloro-3-trifluoromethylphenyl)-isoxazole-4-amine powder was obtained in a yield of 84%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Chloro-4-iodo-2-(trifluoromethyl)benzene, its application will become more common.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2043-57-4 as follows. Recommanded Product: 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane

In the first step, a fluorinated phosphonium salt was synthesized by reacting TPP and 2-perfluorohexyl ethyl iodide accordinto literature procedures [38,39]. Briefly, the fluorinated phosphonium salt was prepared by reacting TPP and fluoroalkyl iodide at 95 C in the absence of solvent. The reaction was continued for 24 h until all of the mixture was solidified. After cooling the resulting solid was washed several times with toluene and ether respectively. Then the white solid was dried at 50 C under vacuum.

According to the analysis of related databases, 2043-57-4, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 82998-57-0, name is 3-Iodo-4-methylbenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Safety of 3-Iodo-4-methylbenzoic acid

To the flask was added 250 ml of thionyl chloride and 26.2 g of 3-iodo-4-methylbenzoic acid, stirred and heated under reflux for 6 h,After drying under reduced pressure, dry dichloroethane was added and the solvent was removed under reduced pressure.Followed by adding 250 ml of chloroform, 20 ml of diisopropylethylamine,A solution of 24.1 g of 3- (4-methylimidazol-1-yl) -5-trifluoromethylaniline, and the temperature was raised to 60 C for 5 h.After completion of the reaction, the solvent was concentrated under reduced pressure to remove the solvent. Add ethyl acetateEster 200ml dissolved, washed 3 times, dried and concentrated, the resulting solid separation by column chromatography, eluentDichloromethane / methanol = 9, the desired fractions were collected and concentrated to give 28 g of a solid in 57% yield.

According to the analysis of related databases, 82998-57-0, the application of this compound in the production field has become more and more popular.

Electric Literature of 444-29-1, A common heterocyclic compound, 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene, molecular formula is C7H4F3I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of aryl halides (0.5 mmol), aryl sulfinates (0.75 mmol), Pd(dppf)Cl2 (2.5 mol percent), P(OPh)3 (5 mol percent), K2CO3 (1.5 mmol) and 2 mL of DMF in a schlenk tube was heated to 150 °C under inert atmosphere (24 h for aryl iodides and 26 h for aryl bromides). The reaction mixture was cooled to room temperature, diluted with ethyl acetate and filtered through a plug of Celite. The filtrate was washed sequentially with H2O and brine. The organic layer was separated, dried (Na2SO4), and concentrated under vacuum. The crude product was purified by column chromatography (silica gel; petroleum ether). All the products were analyzed by GC-MS. 1H NMR, 13C NMR and IR of only representative products are given, as all the products are highly reported.

The synthetic route of 444-29-1 has been constantly updated, and we look forward to future research findings.

Electric Literature of 103440-52-4, The chemical industry reduces the impact on the environment during synthesis 103440-52-4, name is Methyl 2-Iodo-5-methylbenzoate, I believe this compound will play a more active role in future production and life.

Step B: Pd(PPh3)4 (523 mg, 0.45 mmol) was added to a rt solution of methyl 2-iodo-5- methylbenzoate in toluene (23 mL). After the solution was stirred for 10 min, a solution of phenylboronic acid (1 .24 g, 9.96 mmol) in EtOH (10 mL) was added, followed by 2M aq. Na2C03 (21 mL). The mixture was vigorously stirred and heated to reflux for 24h. The rxn mixture was allowed to reach rt, then Et20 was added and the org. layer was separated and concentrated in vacuo. Purification by FC (Biotage SP1 : EtOAc/hept eluting with a gradient of 0-10% EtOAc) was performed to give methyl 4-methyl-[1 , 1 ‘-biphenyl]-2-carboxylate as a colorless oil. LC-MS A: tR = 0.94 min; [M+H]+ = 227.16.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-Iodo-5-methylbenzoate, other downstream synthetic routes, hurry up and to see.