Reference of 627-32-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 627-32-7, name is 3-Iodo-1-propanol belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
25 g (0.134 mol) of 3-iodopropanol, 26 g (0.202 mol) of diisopropylethylamine and 150 mL of 1,2-dichloroethane Add 250mL three-necked flask, cooled to 0 .Under stirring, a solution of 56.9 g (0.202 mol) of trifluoromethanesulfonic anhydride was slowly added dropwise at a temperature of 0 C. After the addition was completed, the temperature was naturally raised to room temperature and the reaction was allowed to proceed overnight.After the reaction was completed, 30 mL dilute hydrochloric acid (0.1 mol / L) was added to the reaction solution, and the mixture was separated by stirring to extract the organic phase. The organic phase was washed with 0.1 mol / L sodium carbonate aqueous solution and saturated sodium chloride aqueous solution, The organic phase was dried over anhydrous sodium sulfate and concentrated to give 33 g of 3-iodopropyltrifluoromethanesulfonate in a yield of 77%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodo-1-propanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Hebei Sangdiya Pharmaceutical Co., Ltd.; Liu Haitao; Yang Xin; Han Yuchao; Ru Qingke; He Lei; Xia Junyi; Lang Hengyuan; (8 pag.)CN106588731; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com