Electric Literature of 6940-76-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6940-76-7, name is 1-Chloro-3-iodopropane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 4-bromo- 2,6-dichlorophenol (10.0 g, 41.1 mmol) and l-chloro-3-iodopropane (10.1 g, 49.0 mmol) in DMF (100 mL) was added CS2CO3 (20.2 g, 61.4 mmol) at 20 C. The reaction was stirred at 70 C for 2 hours. TLC showed the reaction was completed. The resulting solution was cooled down and quenched with water (100 mL), extracted with EtOAc (30 mL x 3). The combined organic layers were washed with brine (100 mL), dried over NaiSOr. filtered and concentrated under reduced pressure. The residue was purified by silica-gel column chromatography to give 5-bromo-l,3-dichloro-2-(3-chloropropoxy)benzene (10.0 g, yield: 76.1%) as yellow oil. NMR (400MHz, CHCb-d) d 7.46 (s, 2H), 4.16 (t, .7=5.75 Hz, 2H), 3.85 (t, .7=6.42 Hz, 2H), 2.29 (t, .7=5.93 Hz, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Chloro-3-iodopropane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ESSA PHARMA, INC.; THE UNIVERSITY OF BRITISH COLUMBIA; PROVINCIAL HEALTH SERVICES AUTHORITY; ZHOU, Han-Jie; VIRSIK, Peter; ANDERSEN, Raymond John; SADAR, Marianne Dorothy; JIAN, Kunzhong; GOLEC, Daniel Andrew; (220 pag.)WO2019/226991; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com