Some common heterocyclic compound, 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, molecular formula is C8H6BrIO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of Methyl 5-bromo-2-iodobenzoate
In a 500-mE round-bottom flask reactor, methyl5-bromo-2-iodobenzoate (25.0 g, 73 mmol), 4-dibenzofuran boronic acid (18.7 g, 88 mmol), tetrakis (triphenylphosphine)palladium (1.7 g, 0.15 mmol), and potassium carbonate (20.2 g, 146.7 mmol) were stirred together with toluene (125 mE), tetrahydrofuran (125 mE), and water (50 mE) for 10 hrs at 80 C. Afier completion of the reaction, the reaction mixture was cooled to room temperature and extracted with ethyl acetate. The organic layer thus formed was separated, concentrated in a vacuum, and purified by column chromatography to afford . (75.0 g, 60.1%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 181765-86-6, its application will become more common.
Reference:
Patent; SFC CO., LTD.; KIM, Hee-Dae; PARK, Seok-Bae; SHIN, Yoona; LEE, Yu-Rim; PARK, Sang-Woo; CHA, Soon-Wook; (81 pag.)US2017/342318; (2017); A1;,
Iodide – Wikipedia,
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