Some common heterocyclic compound, 103962-05-6, name is 1-Iodo-4-(trifluoromethoxy)benzene, molecular formula is C7H4F3IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1-Iodo-4-(trifluoromethoxy)benzene
General procedure: Under argon, imidazo[2,1-c][1,2,4]triazine 1 (100mg, 0.44mmol), (hetero)aryl iodide (0.46mmol) and cesium carbonate (216mg, 0.66mmol) were solubilized in 2mL of toluene. The mixture was evacuated and back-filled with dry argon twice and Xantphos (26mg, 0.044mmol), Palladium acetate (5mg, 0.022mmol) were added and the mixture was submitted to reflux with stirring for 8h. Then cooled to room temperature and the mixture was filtered through celite and the organic phase was extracted three times with ethyl acetate, dried over magnesium sulfate and then concentrated under reduced pressure. The residue was purified by flash chromatography on silica (EtOAc/EP 2:8 to 3:7) to provide the desired product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 103962-05-6, its application will become more common.
Reference:
Article; Loubidi, Mohammed; Jouha, Jabrane; Tber, Zahira; Khouili, Mostafa; Suzenet, Franck; Akssira, Mohamed; Erdogan, Muemin Alper; Koese, Fadime Ayd?n; Dagc?, Taner; Armagan, Gueliz; Saso, Luciano; Guillaumet, Gerald; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 113 – 123;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com