116632-39-4, name is 5-Bromo-2-iodotoluene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 116632-39-4
A mixture of 5-bromo-2-iodotoluene (25.0g, 0.1mol), NBS (36.6g, 0.1mol), and BPO (0.6g, 2.6mmol) were dissolved in 200mL of CCl4 and refluxed. The mixture was allowed to stir until the completion of the reaction, which was confirmed by thin layer chromatography (TLC) analysis (7h). When the reaction ended, a large amount of the floating succinimide produced in the reaction systems was filtrated off. The filtrate was evaporated to remove the solvent. The crude product was purified by column chromatography on silica with petroleum ether as the eluent to give 16.3g of a white solid 5-bromo-2-iodobenzyl bromide. Yield:50%; 1H NMR (600MHz, CDCl3): delta=4.52 (s, 2H, Ph-CH2), 7.21-7.59(m, 3H, Ar-H) ppm.
The synthetic route of 116632-39-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Guan; Jia; Zhang; Zhang; Ma; Lu; Lai; Lei; Dyes and Pigments; vol. 136; (2017); p. 873 – 880;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com