Related Products of 629-09-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 629-09-4, name is 1,6-Diiodohexane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Sodium methoxide (25 wt. %, 5.5 mL, 24.1 mmol) was added bysyringe to 20 (4.0 mL, 24.3 mmol) in DMF (10 mL) over 20 min. Thereaction solution was heated at 63 C for 17 h. After cooling to 0 C,the reaction solution was treated with 3:1 cold 0.5 M HCl/6 M NaCl(200 mL) and was extracted with EtOAc (2 150 mL, 50 mL). Theorganic extracts were washed with 1% NaHSO3 (150 mL), H2O(2 150 mL) and 6 M NaCl (100 mL), and solvent was removedby rotary evaporation. Flash column chromatography using 4%then 6% EtOAc/petroleum ether furnished 1.61 g of 2174 (28%) asa liquid: 1H NMR d 3.37 (t, J = 6.4 Hz, 2H), 3.33 (s, 3H), 3.19 (t,J = 7.0 Hz, 2H), 1.83 (quintet, J = 7.1 Hz, 2H), 1.54-1.62 (m, 2H),1.33-1.46 (m, 4H). 13C NMR d 72.78, 58.72, 33.58, 30.46, 29.57,25.26, 7.25. HRMS m/z calcd for C7H19INO, 260.0506 (M+NH4);found, 260.0515. Anal. Calcd for C7H15IO: C, 34.73; H, 6.25.Found: C, 34.44; H, 6.19.
The synthetic route of 1,6-Diiodohexane has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bergeron, Raymond J.; Bharti, Neelam; McManis, James S.; Wiegand, Jan; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5954 – 5971;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com