Synthetic Route of 13421-00-6,Some common heterocyclic compound, 13421-00-6, name is 5-Chloro-2-iodobenzoic acid, molecular formula is C7H4ClIO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of S-chloro-2-iodobenzoic acid (3.0 g,10.62 mmol), 50C12 (12 mE) and DMF (0.6 mE) was gently warmed with a heat gun until the mixture became homogeneous (15 mm). The solution was maintained at 23 C. for additional 30 mm and then the solution was concentrated. MeOH (24 mE) was added to the crude residue and the solution was maintained at 23 C. for 30 mm. The solution was concentrated and the residue was purified by flash chromatography on l3iotage silica gel cartridge (cyclohexane to cyclohexane_EtOAc=85: 15) to afford methyl S-chloro-2-io- dobenzoate (3.02 g, 10.20 mmol, 96%).
The synthetic route of 13421-00-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CHIESI FARMACEUTICI S.p.A.; Biagetti, Matteo; Capelli, Anna Maria; Accetta, Alessandro; Carzaniga, Laura; US2015/166549; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com