Reference of 811842-30-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 811842-30-5, name is 2-Bromo-1-fluoro-4-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Into a 1 L four-necked round bottom flask equipped with a stirrer, an Erlin condenser, a nitrogen inlet tube, and a thermometer, 22.3 g (105.2 mmol) of 4-dibenzofuran boronic acid of Synthesis Example 8,34.7 g (115.6 mmol) of 3-bromo-4-iodo-1-fluorobenzene of Synthesis Example 23, 350 mL of toluene, 175 mL of ethanol, 29.0 g (209.8 mmol) of potassium carbonate and 105 mL of water were charged, , And the mixture was stirred at room temperature for 30 minutes. Subsequently, 0.12 g (0.54 mmol) of palladium acetate and 0.32 g (1.07 mmol) of tri (o-tolyl) phosphine were added and heated, followed by stirring at a reflux temperature for 2 hours. The resulting reaction solution was cooled to room temperature, the aqueous layer was separated, and extracted twice with 150 mL of ethyl acetate. The organic layers were combined, washed with 150 mL of saturated brine, dried over magnesium sulfate, magnesium sulfate was removed by suction filtration, and the solvent was distilled off under reduced pressure. Subsequently, the obtained oily matter was separated by silica gel column chromatography with a mixed solvent of n-heptane and toluene to obtain 32.4 g (yield: 90.3%) of the desired bromide.
The synthetic route of 2-Bromo-1-fluoro-4-iodobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; YAMAGATA UNIVERSITY; CHEMIPRO KASEI KAISHA LIMITED; KIDO, JUNJI; SASABE, HISAHIRO; TAKAHASHI, JUN; NAGAI, NAGAI; (723 pag.)JP2018/90561; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com