These common heterocyclic compound, 455-13-0, name is 4-Iodobenzotrifluoride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H4F3I
General procedure: Et3N (10 mL) and THF (10 mL) were added to 4-methoxyiodobenzene19c (1.05 g, 4.5 mmol), CuI (87 mg, 450 mmol), (Ph3P)2PdCl2(158 mg, 225 mmol) and Na ascorbate (89 mg, 450 mmol) under Ar. The mixturewas stirred at 40C for 30 min. Me3SiCCH (1.03 g, 10.5 mmol) was added and the mixture was stirred at 40C for16 h. The evaporation residue, in CH2Cl2, was washed (water,2 ) and dried. Chromatography(petroleum ether / EtOAc 99:1) gave 20c (909 mg, 99%) as an oil (lit.2oil).
The synthetic route of 4-Iodobenzotrifluoride has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kumpan, Katerina; Nathubhai, Amit; Zhang, Chenlu; Wood, Pauline J.; Lloyd, Matthew D.; Thompson, Andrew S.; Haikarainen, Teemu; Lehtioe, Lari; Threadgill, Michael D.; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3013 – 3032;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com