Related Products of 54413-93-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 54413-93-3 as follows.
2~lodo-5-methoxybeiizoie acid (1.74 g, 6.25 mmol), /V-(3-dimethylaminopropyl)-AT- ethylcarbodiimide hydrochloride (1.44 g, 7.5 mmol), l-hydroxybenzotriazole (676 mg, 5.0 mmol), Ar, V-diisopropy]ethylamine (2.61 mL, 15.0 mmol), and benzylamine (546 pL, 5.0 mmol) were dissolved m anhydrous DMF (12.5 mi.) and stirred at room temperature for 16 hours. The reactin mixture was diluted with an excess of EtOAc and washed five times with water and brine. The organic layer was dried over Na2S04, filtered and concentrated. The residue was purified by flash column chromatography (EtOAc : DCM = 0; 100 to 30:70) to give V-benzyl-2-iodo-5-methoxybenzamide (1.534 g, 84%) as a white solid.
According to the analysis of related databases, 54413-93-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael S.; DE CLERCQ, Dries; JANG, Jaebong; JANNE, Pasi; TO, Ciric; ECK, Michael; PARK, Eunyoung; HEPPNER, David; (0 pag.)WO2019/164953; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com