Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Bromo-1-iodo-2-nitrobenzene
Intermediate M2-b (4.8 g, 15 mmol), 2-iodo-5-bromonitrobenzene (5.9 g, 18 mmol),Sodium tert-butoxide (2.9 g, 30 mmol), 50 mL of toluene, protected with nitrogen,0.17 g of d2(dba)3, tri-tert-butylphosphine (11 ml, 10% in toluene),The stirring was started, and the mixture was heated to reflux at 100 C for 12 hours.The reaction solution is washed with water, and the organic phase is concentrated and passed through a silica gel column.The eluent is petroleum ether: ethyl acetate = 50:1, concentrated eluent,Obtaining intermediate M2-c(6.6 g, yield 84.6%).
According to the analysis of related databases, 112671-42-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Fan Hongtao; Zhang Yaguang; Zhang Xianghui; Ren Xueyan; (39 pag.)CN108341824; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com