Related Products of 460-37-7, These common heterocyclic compound, 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of Zinc ((1 S,3S)-3-(methyl(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)amino)cyclobutyl)-methanesulfinate (100 mg, 0.230 mmol) in DMSO (8 mL) was added 1 ,1 ,1 – trifluoro-3-iodopropane (1 29 mg, 0.575 mmol) and K2CO3(95.4 mg, 0.690 mmol). The solution was stirred at 50oC for 2 hours by which time LCMS showed the reaction was complete. The mixture was diluted with water (30 mL), extracted with EtOAc (30 mL x 2). The combined organ- ic layer was washed with brine (50 mL), dried over Na2SO4, filtered and concentrated. The crude product was purified by silica gel chromatography (EtOAc: PE=2:1 ) to afford the title compound (45 mg, 37%) as a colorless oil. LCMS m/z 531 .1 [M+H]+
Statistics shows that 1,1,1-Trifluoro-3-iodopropane is playing an increasingly important role. we look forward to future research findings about 460-37-7.
Reference:
Patent; PFIZER INC.; COFFMAN, Karen J.; DUERR, James M.; KAILA, Neelu; PARIKH, Mihir D.; REESE, Matthew R.; SAMAD, Tarek; SCIABOLA, Simone; TUTTLE, Jamison B.; VAZQUEZ, Michael L.; VERHOEST, Patrick Robert; (254 pag.)WO2016/24185; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com