Reference of 627-31-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 627-31-6, name is 1,3-Diiodopropane(stabilized with Copper chip), This compound has unique chemical properties. The synthetic route is as follows.
Example 4General Procedure for the Preparation of Alkyl Ester IodidesAlkyl ester iodides were prepared via reaction between methyl 2-methylpropanoate and appropriate alkyl diodide in the presence of butylithium and diisopropylamine according to the following process: under inert atmosphere, N,N-diisopropylamine (1.1eq) was dissolved in tetrahydrofuran (10eq). To the solution cooled down to 0 C. was added n-butyllithium (1.1eq) drop by drop. The solution was then cooled to -70 C. before adding 2-methylpropanoic acid (1eq). The mixture was stirred at -70 C. for 15 minutes. The appropriate diiodated derivative (2eq) was added drop by drop at -70 C., and then the reaction mixture was gradually warmed to room temperature and stirred for 20 hours. The solution was then hydrolysed by adding HCl 2N to reach acidic pH. The aqueous layer was extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, filtered, and evaporated under reduced pressure. The residue was chromatographed over silica gel.Example 4.1 methyl 2,2-dimethyl-5-iodo-pentanoate Prepared following the general procedure previously described using methyl 2-methylpropanoate and 1,3-diiodopropane. The residue was chromatographed over silica gel (eluent cyclohexane). The product was obtained as a pale yellow oil. Yield: 79% Rf (cyclohexane/ethyl acetate 98/2): 0.32 NMR 1H (CDCl3): 1.20 (s, 6H); 1.62 (m, 2H); 1.78 (m, 2H); 3.15 (t, 2H, J=7 Hz); 3.69 (s, 2H).
The chemical industry reduces the impact on the environment during synthesis 1,3-Diiodopropane(stabilized with Copper chip). I believe this compound will play a more active role in future production and life.
Reference:
Patent; GENFIT; US2010/4159; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com