Application of 31599-61-8, These common heterocyclic compound, 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture containing aryl halide (5.0 mmol), styrene(5.0 mmol), the palladium complex 5a (0.005 mmol) and potassium carbonate (1.06 g, 10.0 mmol) in methanol (20 ml) was refluxed for 2 h, as mentioned in Table 4. After the reaction, the solvent was evaporated, the product was poured into water, extracted with diethyl ether, dried over Na2SO4 and passed through a 1200 silica column (60-120 mesh). Upon evaporation of the ether, solid pure products were obtained. The yields of the products obtained from all the reactions were determined after isolation and the products characterized by 1H NMR spectra (Table 7).
Statistics shows that 4-Iodo-1,2-dimethylbenzene is playing an increasingly important role. we look forward to future research findings about 31599-61-8.
Reference:
Article; Pattanayak, Poulami; Pratihar, Jahar Lal; Patra, Debprasad; Brandao, Paula; Felix, Vitor; Chattopadhyay, Surajit; Polyhedron; vol. 79; (2014); p. 43 – 51;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com