Reference of 160976-02-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 160976-02-3 as follows.
To a solution of 5-bromo-1,3-difluoro-2-iodobenzene (10.0 g, 0.048 mol) in N-methyl pyrrolidone (50 mL) was added CuCN (5.2 g, 0.057 mol). The reaction mixture was heated toreflux for 1.5 h. The reaction mixture was added EDTA, water and extracted with EtOAc. The organic layers were dried over Na2504 and concentrated to afford 1.6 g of title compound.
According to the analysis of related databases, 160976-02-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; MUTHUKAMAN, Nagarajan; PISAL, Dnyandeo; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy Manish; KADAM, Sheetal R; (303 pag.)WO2016/55947; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com