Adding a certain compound to certain chemical reactions, such as: 148870-57-9, name is 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 148870-57-9, Application In Synthesis of 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
To a mixture of (S)-N-[(4,5-dimethoxybenzocyclobut-l-yl)-methyl]-N-(methyl)amine (42g) and N,N-dimethylformamide (220ml) was charged 7,8-dimethoxy-3-[3-iodopropyl]-l,3-dihydro-2H- 3-benzazepin-2-one (75g) and potassium carbonate (42g) at room temperature. The reaction mixture was heated and stirred the reaction mass at 50-55 C for 2 hours and the completion of reaction was monitored by HPLC/TLC. After completion of reaction, reaction mass was cooled to 25-30 C and diluted with dimineralized water (1000ml). The reaction mixture was extracted with methylene dichloride (400ml x 200ml) and the layers were separated. Methylene chloride was distilled off completely. To the residue, dimineralized water (200ml) and hydrochloric acid (50ml) were added and the aqueous solution is washed with ethyl acetate (200ml x 3). The layers were separated and to the aqueous layer 50 % (w/v) sodium hydroxide solution (120ml) was added at 25-30 C. The aqueous layer was extracted with ethyl acetate (400ml + 200 ml) and the combined ethyl acetate layer was washed with 5 %( w/v) sodium hydroxide solution (300ml). Ethyl acetate layer was dried over anhydrous sodium sulfate and then ethyl acetate was distilled out completely under vacuum to get the title compound.
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Reference:
Patent; IND-SWIFT LABORATORIES LIMITED; WO2008/146308; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com