Application of 60577-34-6, These common heterocyclic compound, 60577-34-6, name is 4-Iodo-N-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A 50 mL round bottom flask was charged with compound 12 (1 equivalent), CuI (0.40.5 equivalents), anhydrous K2CO3 (2-4 equivalents), pipecolinic acid (0.81.0 equivalents) and appropriate iodobenzene (2-3 equivalents). The flask was connected to a vacuum for 3 min, followed by addition of anhydrous DMF using a syringe. The flask was purged with argon for 5 min and then heated in an oil bath maintained at 110 C. On heating, the color of the suspension turned orange/pink, and this color change lasted for about 2 h. The reaction was stirred for an additional 22 h at 110 C. The reaction mixture was then allowed to cool to room temperature. Ethyl acetate (25 mL) was added, and the mixture was poured into water (100 mL). The product was extracted with ethyl acetate (100 mL × 2). The combined organic extracts were washed with brine (100 mL) and dried (anhydrous Na2SO4) and concentrated under reduced pressure. Silica gel (500 mg) was added and the solvent evaporated to obtain a plug, which was purified by column chromatography using hexanes and ethyl acetate (10:1 to 2:1). Fractions containing the product (TLC) were pooled and evaporated to afford 14, 17, and 18 in 27-36% yield.
The synthetic route of 60577-34-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Devambatla, Ravi Kumar Vyas; Choudhary, Shruti; Ihnat, Michael; Hamel, Ernest; Mooberry, Susan L.; Gangjee, Aleem; Bioorganic and Medicinal Chemistry Letters; vol. 28; 18; (2018); p. 3085 – 3093;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com