Adding a certain compound to certain chemical reactions, such as: 2265-91-0, name is 1,3-Difluoro-5-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2265-91-0, Product Details of 2265-91-0
General procedure: o-hydroxy-cinnamate ester 1 (0.5 mmol,), aryl iodides 2 (1.0 mmol, 2.0 equiv), Pd(OAc)2 (0.05 mmol, 10 mol %), and H2O (1ml) was charged into a pressure tube. The reaction mixture was stirred at 100 C for 12 h under air. After cooled to room temperature, the reaction mixture was diluted with EtOAc (5 mL) and washed with NH4Cl (3 x 5 mL). The organic phase was separated, dried over NaSO4 and the solvent was removed in vacuo. The residue was purified by column chromatography by using hexanes/ethyl acetate as eluent to afford the desired products 3a-z.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3-Difluoro-5-iodobenzene, and friends who are interested can also refer to it.
Reference:
Article; Chen, Junmin; Liu, Wei; Zhou, Liandi; Zhao, Yongli; Tetrahedron Letters; vol. 59; 26; (2018); p. 2526 – 2531;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com