Reference of 755027-21-5, The chemical industry reduces the impact on the environment during synthesis 755027-21-5, name is 4-Chloro-1-iodo-2-methoxybenzene, I believe this compound will play a more active role in future production and life.
A mixture of Example 56A (67mg, 0.2 MMOL), Example 59B (37mg, 0.2 mmol), CYMAP ligand (11. 8mg, 0.03 mmol), Pd (OAc) 2 (4.9mg, 0.002 mmol), and CsF (91MG, 0.6 mmol) in DME (8 mL) and methanol (4 mL) was heated to reflux overnight, cooled to room temperature, and partitioned between water and ethyl acetate. The aqueous layer was extracted with ethyl acetate and the combined organic layers were washed with brine, dried (MGS04), filtered, and concentrated under vacuum. The residue was purified by flash column chromatography on silica gel with 1: 1 HEXANES/ETHYL acetate to provide 0.036g (50%) of the desired product. MS (ESI) m/e 359 (M+H) + ; 1H NMR (300 MHz, DMSO-d6) 8 9.88 (s, 1H), 7.99 (s, 1H), 7.79 (d, J = 8.14 Hz, 1H), 7.70 (d, J = 8.14 Hz, 1H), 7.27-7. 36 (m, 3H), 6.91-7. 01 (m, 5H), 4.00 (s, 3H), 2.56 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-1-iodo-2-methoxybenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ABBOTT LABORATORIES; WO2004/76424; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com