Synthetic Route of 645-00-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 645-00-1, name is 1-Iodo-3-nitrobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: A mixture of aryl halide (0.1mmol) and KOH (0.3mmol), was added to a mixture of DMF (2mL) and ChCl·CuCl (20mol%) under an N2 atmosphere in a round-bottom flask equipped with a condenser. The mixture was heated in an oil bath at 140C and then phenylacetylene (0.15mmol) was added in three portions. The mixture was stirred continuously during the reaction and monitored by both thin-layer chromatography and gas chromatography (GC). After the reaction was complete, the mixture was cooled to room temperature and diluted with EtOAc and H2O. The organic phase was dried over CaCl2, filtered, and concentrated under reduced pressure using a rotary evaporator. The residue was purified by silica gel column chromatography. The products were characterized by IR, 1H NMR, 13C NMR, and GC-MS.
The synthetic route of 1-Iodo-3-nitrobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Hajipour, Abdol R.; Nazemzadeh, Seyed Hadi; Mohammadsaleh, Fatemeh; Tetrahedron Letters; vol. 55; 3; (2014); p. 654 – 656;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com