Reference of 1133123-02-0,Some common heterocyclic compound, 1133123-02-0, name is 4-Bromo-2-iodobenzoic acid, molecular formula is C7H4BrIO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of 4-bromo2-iodobenzoic acid 319a (3 0 g, 1 equiv.) in THF (405 mL) was added di-tert-butyl dicarbonate (3.0 g, 1.5 equiv.), TEA (3.2 mL, 2.5 equiv.) andDMAP (1. 1 g, 1.0 equiv.). The reaction mixture was stirred at room ternperature for 16 h,diluted with ethyl acetate, and washed with water, brine, dried over sodium sulfate, filteredand concentrated under reduced pressure. The residue was purified by silica gelchromatography eluting with 3-5~o ethyl acetate in hexanes to give the tert-bu1yl4-bromo-2-10 iodobenzoate 319b (1.9 g) as a liquid. 1HNMR (400 MHz, DMSO-d6) 8: 8. J 8 (d, l”l.9 Hz,1H), 7.76-7.60 (m lH), 7.54 (d, J = 8.3 Hz, lH), 156 (bs, 9H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-2-iodobenzoic acid, its application will become more common.
Reference:
Patent; ARDELYX, INC.; CHAO, Jianhua; JAIN, Rakesh; HU, Lily; LEWIS, Jason Gustaf; BARIBAULT, Helene; CALDWELL, Jeremy; (582 pag.)WO2018/39386; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com