Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14452-30-3, name is 1-(3-Iodophenyl)ethanone, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-(3-Iodophenyl)ethanone
1-[3-(2,6-difluorobenzyl)-phenyl]-ethanone (8A). A suspension of Dibromoethane (0.28 mL, 0.0032 mole) in 35 mL of THF under Argon was treated with activated zinc (10.5 g, 0.161 mole) and heated to reflux 2 times for 30 seconds each time. The suspension was then cooled in a salt water ice bath to -8 C. and 2,6-Difluorobenzyl bromide (16.8 g, 0.081 mole) in 20 mL of THF was added dropwise. After addition was completed the reaction was allowed to stir at 0 C., for 1 hour. In a separate flask was added Bis(dibenzylideneacetone)palladium (3.1 g, 0.00537 mole), Tri(2-furyl) phosphine (2.5 g, 0.0107 mole), and 3-iodoacetophenone (13 g, 0.0537 mole) to 40 mL of THF and cooled to 0 C. The zinc suspension was then cannulated into the 3-iodoacetophenone mixture and the ice bath was removed. After 18 hours the mixture was filtered through a pad of celite and washed several times with EtOAc and then the solvents were removed under reduced pressure. The residue was treated with 150 mL of a saturated aqueous solution of NH4Cl and extracted with EtOAc three times, the combined organic layers were dried over NaSO4, filtered and evaporated to give a brown oil. This crude product was flash chromatographed with 15% EtOAc/Hexanes to give 1-[3-(2,6-difluoro-benzyl)-phenyl]-ethanone (8A) as a yellow oil. Rf=0.56 (15% EtOAc/Hexanes). 1H NMR (400 MHz, CDCl3) delta 7.86 (s, 1H), 7.78 (d, j=7.6 Hz, 1H), 7.45 (d, j=8.3 Hz, 1H), 7.36 (t, j=7.6 Hz 1H), 7.19 (m, 1H), 6.89 (m, 2H), 4.07 (s, 2H), 2.57 (s, 3H)
According to the analysis of related databases, 14452-30-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Payne, Linda S.; Tran, Lekhanh O.; Zhuang, Linghang H.; Young, Steven D.; Egbertson, Melissa S.; Wai, John S.; Embrey, Mark W.; Fisher, Thorsten E.; Guare, James P.; Langford, H. Marie; Melamed, Jeffrey Y.; Clark, David L.; US2003/229079; (2003); A1;,
Iodide – Wikipedia,
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