Electric Literature of 153898-63-6, These common heterocyclic compound, 153898-63-6, name is 2-Iodo-5-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Bis(triphenylphosphine)palladium(ll) dichloride (32,1 mg; 45,8 muiotatauiotaomicronIota), copper(l) iodide (17,8 mg; 91,5 muiotatauiotaomicronIota), 2-lodo-5-methoxyaniline (1,2 g; 4,6 mmol), phenylacetylene (573 ml; 5,5 mmol), and diethylamine (10 ml) are refluxed for 2 h. The residue is chromatographed on silica gel (heptane/EE, 10/1) to afford 5-methoxy-2-(phenylethynyl)aniline (818 mg; 3.7 mmol; 80% of theory). 1H NMR (500 MHz, Chloroform-d) delta 7.54 (d, J = 6.7 Hz, 2H), 7.36 (q, J 8.9, 7.7 Hz, 2H), 7.32 (q, J = 8.9, 8.5 Hz, 2H), 6.34 (dd, J = 8.5, 2.4 Hz, 1H), 6.30 (d, J = 2.3 Hz, 1H), 3.82 (s, 3H).
Statistics shows that 2-Iodo-5-methoxyaniline is playing an increasingly important role. we look forward to future research findings about 153898-63-6.
Reference:
Patent; MERCK PATENT GMBH; DOBELMANN-MARA, Lars; RIEDMUELLER, Stefan; SCHRAUB, Martin; (166 pag.)WO2018/149853; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com