Reference of 72373-82-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 72373-82-1, name is 1-Chloro-2-fluoro-3-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Intermediate 17A. Ethyl l-(3-chloro-2-fluorophenyl)-lH-imidazole-4- carboxylate, 1 HQ: A mixture of l-chloro-2-fluoro-3-iodobenzene (0.549 g, 2.141 mmol), ethyl lH-imidazole-4-carboxylate (0.3 g, 2.141 mmol), copper(I) iodide (0.082 g, 0.428 mmol), L-proline (0.099 g, 0.856 mmol), and K2C03 (0.888 g, 6.42 mmol) in DMSO (4.28 mL) was vacuumed and back-filled with argon for three times, then capped and heated at 110 °C. After 20 h, the reaction mixture was cooled to room temperature and diluted with EtOAc. The organic layer was washed with H20, brine, dried over Na2S04, filtered, and concentrated. The crude product was then purified using reverse phase HPLC chromatography to yield the desired product (0.01 g, 1.2percent) as a colorless oil. MS (ESI) m/z: 269.0 (M+H)+.Intermediate 17A. Ethyl l-(3-chloro-2-fluorophenyl)-lH-imidazole-4- carboxylate, 1 HQ: A mixture of l-chloro-2-fluoro-3-iodobenzene (0.549 g, 2.141 mmol), ethyl lH-imidazole-4-carboxylate (0.3 g, 2.141 mmol), copper(I) iodide (0.082 g, 0.428 mmol), L-proline (0.099 g, 0.856 mmol), and K2C03 (0.888 g, 6.42 mmol) in DMSO (4.28 mL) was vacuumed and back-filled with argon for three times, then capped and heated at 110 °C. After 20 h, the reaction mixture was cooled to room temperature and diluted with EtOAc. The organic layer was washed with H20, brine, dried over Na2S04, filtered, and concentrated. The crude product was then purified using reverse phase HPLC chromatography to yield the desired product (0.01 g, 1.2percent) as a colorless oil. MS (ESI) m/z: 269.0 (M+H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Chloro-2-fluoro-3-iodobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; PINTO, Donald J.P.; CLARK, Charles G.; SMITH, II, Leon M.; ORWAT, Michael J.; JEON, Yoon; CORTE, James R.; WO2014/160668; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com