Reference of 64248-58-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 64248-58-4 name is 1,2-Difluoro-4-iodobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a degassed (argon) solution of 1,3-dihydro-2H-imidazol-2-one (1.75 g, 18.75 mmol) and 3,4-difluoroiodobenzene (3 g, 12.5 mmol) in dimethylsulfoxide (20 mL) was added, palladium(II) acetate (0.14 g, 0.62 mmol) and sodium acetate trihydrate (3.07 g, 37.5 mmol) at ambient temperature. The reaction mixture was further degassed with argon and stirred at 80 C for 16 h. The reaction mixture was cooled to ambient temperature, filtered through Celite diatomeaceaus earth filter aid and washed with ethyl acetate (2 × 50 mL). The filtrate was then washed with water (2 × 25 mL) and the crude product was purified by silica gel chromatography. Elution with 5% methanol in dichloromethane provided the title compound as a white solid (670 mg). 1H NMR (400MHz) delta 6.97 (s, 1H), 7.34-7.44 (m, 2H), 7.55-7.61 (m, 1H), 10.12 (s, 1H), 10.54 (s, 1H). MS (M+1) = 195.2
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2-Difluoro-4-iodobenzene, and friends who are interested can also refer to it.
Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; SATTERFIELD, Andrew Duncan; (105 pag.)WO2017/23515; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com